School of Medical & Allied Sciences Faculty

Dr. Rahul Pratap Singh

Associate Professor, Pharmaceutics

Qualification: M. Pharm. and B. Pharm., Ph.D.

College/University: Bundelkhand University, Jhansi, Banaras Hindu University, Varanasi

Introduction: Rahul Pratap Singh is an expert in the area of Pharmaceutics (Cancer Nanotechnology) with a strong background in fabrication and characterization of pharmaceutical dosage forms using advanced scientific tools. His research focuses on cancer nanomedicine, protein, peptides and receptor binding, xenograft modeling, multi-functionalized nanomedicines to improve the safety profile of chemotherapeutics and therapeutic outcomes in cancer patients

He has tough pharmaceutics-related subjects to undergraduate and diploma pharmacy students. Before joining up GD Goenka University in 2017, Dr. Singh served as a Junior and Senior Research Fellow at Banaras Hindu University, Varanasi. He also worked in Formulation and Development (F&D) (complex injectable) as a Research Associate in Mankind Research Centre, Gurugram, India. Rahul Pratap Singh holds a Ph.D. from the Banaras Hindu University, Varanasi; M. Pharm. and B. Pharm. from the Bundelkhand University, Jhansi.

Publications (from 2015)

Scopus Indexed Articles (Scholarly Journals)

‘Transferrin receptor targeted PLA-TPGS micelles improved efficacy and safety in docetaxel delivery’. International Journal of Biological Macromolecules,83, pp. 335-344 (Singh, R.P., Sharma, G., Sonali, et al., 2016). (Impact Factor: 5.162)

‘Vitamin E TPGS conjugated carbon nanotubes improved efficacy of docetaxel with safety for lung cancer treatment’. Colloids and Surfaces B: Biointerfaces.141, pp. 429-442 (Singh, R.P., Sharma, G., Sonali., 2016). (Impact Factor: 4.389)

‘Transferrin liposomes of docetaxel for brain-targeted cancer applications: formulation and brain theranostics.’Drug Delivery.23(4), pp. 1261-1271. (Sonali, Singh, R.P., Singh, N., 2016). (Impact Factor: 4.902)

‘Transition from passive to active targeting of oral insulin nanomedicines: Enhancement in bioavailability and glycemic control in diabetes.’ Nanomedicine. 11(11), pp. 1465-1486. (Kaklotar, D., Agrawal, P., Singh, R.P., 2016). (Impact Factor: 4.3)

‘Transferrin receptor-targeted vitamin E TPGS micelles for brain cancer therapy: preparation, characterization and brain distribution in rats’. Drug Delivery. 23(5), pp. 1788-1798. (Sonali, Agrawal, P., Singh, R.P., 2016). (Impact Factor: 4.902)

‘Effects of transferrin conjugated multi-walled carbon nanotubes in lung cancer delivery’.’ Materials Science and Engineering C. 67, pp. 313-325. (Singh, R.P., Sharma, G., Sonali, 2016). (Impact Factor : 5.880)

‘RGD-TPGS decorated theranostic liposomes for brain targeted delivery’. Colloids and Surfaces B: Biointerfaces. 147, pp. 129-141. (Sonali, Singh, R.P., Sharma, G., 2016). (Impact Factor: 4.389)

‘Bioadhesive micelles of D-α-tocopherol polyethylene glycol succinate 1000: Synergism of chitosan and transferrin in targeted drug delivery’. Colloids and Surfaces B: Biointerfaces. 152, pp. 277-288. (Agrawal, P., Sonali, Singh, R.P., 2017). (Impact Factor: 4.389)

‘TPGS-chitosan cross-linked targeted nanoparticles for effective brain cancer therapy’. Materials Science and Engineering C. 74, pp. 167-176 (Agrawal, P., Singh, R.P., Sonali, 2017). (Impact Factor : 5.880)

‘Chitosan-folate decorated carbon nanotubes for site specific lung cancer delivery’. Materials Science and Engineering C. 77, pp. 446-458. (Singh, R.P., Sharma, G., Sonali, 2017). (Impact Factor : 5.880)

‘Nanotheranostics: Emerging strategies for early diagnosis and therapy of brain cancer’. Nanotheranostics. 2(1), pp. 70-86. (Sonali, Viswanadh, M.K., Singh, R.P., 2018)

‘Fabrication of a novel drug-resin combination device for controlled release of dextromethorphan hydrobromide’. Colloids and Surfaces B: Biointerfaces. 189, 110833. (Liu, H., Hua, L., Singh. R.P., 2020). (Impact Factor: 4.389)

‘Preparation and characterization of advanced resin based drug delivery system to improve therapeutic efficacy of huperzine A’. Journal of Drug Delivery Science and Technology, (Yu, J., Zhang, Z., Li, X., Singh, R.P., 2021). (Impact Factor: 2.734)

‘Microfluidic Assembly: An Innovative Tool for the Encapsulation, Protection, and Controlled Release of Nutraceuticals’. Journal of Agricultural and Food Chemistry. 69(10), pp. 2936-2949. (Liu, H., Singh, R.P., Zhang, Z., 2021). (Impact Factor: 4.192)

Books

‘Novel drug carriers: Formulation and evaluation of nimesulide loaded microspongic gel for topical pain and inflammation disease treatments’. Lambert Academic Publishing. (Singh, R.P., Prajapati, S.K., Singh, S. 2014).

‘Microsponges for colon drug delivery: Preparation and characterization of prednisolone loaded microsponges’. Lambert Academic Publishing. (Singh, S., Prajapati, S.K., Singh, R.P., 2014).

‘Nanomedicines: Potential tools in drug delivery for lung cancer treatment’. Woodhead Publishing India Pvt. Ltd. (Singh, R.P., Singh, S., Prajapati, S.K., Dutt., Hu, L., under communication)

Research

Dr. Singh research work is at the interface of nanobiotechnology and materials science. The main focus is the study and development of biodegradable novel nanocarriers to the successful delivery of bioactive molecules, especially natural and engineered nucleic acids, proteins, peptides, continuously at controlled rates for prolonged periods.

Work is in progress in the following areas;

• Investigating the mechanism of release of bioactive molecules from nanocarriers (nanomedicines) with physicochemical analysis and pharmacokinetic modeling
• Study on pharmacological aspects of nanocarriers (nanomedicines) including in-vitro and in-vivo therapeutic efficacy and safety for anticancer drugs.
• Developing controlled release systems that can be embedded with the theranostic approach for simultaneous controlled delivery of therapeutic agents and diagnostic agents in cancer therapy.
• Synthesizing new biodegradable drug delivery platforms which will ultimately be absorbed by the body.
• Fabrication of new technologies for the effective delivery of bioactive molecules such proteins, peptides, nucleic acids, and drugs across complex barriers in the body such as the blood-brain barrier, the breast, and the lung.

Contribution to the Profession and Awards (from 2015)

Editor in Journal

Coronaviruses (Bentham Science)
Recent Patents on Inflammation & Allergy Drug Discovery (Bentham Science)
Coronaviruses (Bentham Science)
Current Proteins and Peptides (Bentham Science)
International Research Journal of Pharmacology (Science Range Publications)
Acta Scientific Pharmaceutical Sciences (Acta Scientific)

Reviewer for Funding Agencies and Journals

Department of Science and Technology (DST), New Delhi – Funding Agency – India
Science and Engineering Research Board (SERB), New Delhi – Funding Agency – India
Impacting Research Innovation and Technology (IMPRINT)-Research Funding Program-India
International Journal of Pharmaceutics - Journal – Elsevier
European Journal of Pharmaceutics and Biopharmaceutics- Journal – Elsevier

National Award for Excellence in Research

Gandhian Young Technology Innovation Award 2017 during the Festival of Innovations (FOIN), hosted by The Office of the President of India, Rashtrapati Bhavan, New Delhi

Scholarship and Fellowship

Received Scholarship from Ministry of Human Resource Development, New Delhi during M. Pharmacy from July 2009 to June 2011
Received Junior Research Fellowship from University Grants Commission, New Delhi from April 2012 to March 2013
Received Senior Research Fellowship from University Grants Commission, New Delhi from April 2015 to October 2016

Professional Recognitions

Lifetime membership of Association of Pharmaceutical Teachers of India, from October 2017

Current Research

Dr. Singh and his research group focus to develop multi-functionalized and biodegradable nanomedicine systems for the delivery of bioactive agents for cancer therapy. Recently, he has received a research grant worth Rupees Forty-One Lakh from theScience and Engineering Research Board (SERB), Department of Science and Technology (DST), Government of Indiato conduct translational research in the area of cancer nanotheranostics..